Through an existing collaboration, the Smart Biomaterials Consortium (SBMC) and Ourobionics, is spearheading the development of a next-generation 3D human skin model designed to transform pharmaceutical testing. This innovative platform will serve as a highly physiologically relevant in-vitro system for evaluating transdermal drug delivery technologies, with a particular focus on emerging modalities such as temporary tattoo-based devices. 

At the heart of this initiative is Ourobionics’ patented 3D bioelectric field deposition technology, which enables the fabrication of multi-layered skin constructs that closely replicate the structural, functional, and biochemical characteristics of native human skin. These constructs will be produced within SBMC’s GMP-compliant manufacturing facilities, ensuring consistency, scalability, and regulatory alignment throughout the development process. 

The engineered skin models will be rigorously tested to assess drug release information, penetration depth, and biocompatibility. The project aims to achieve predictive accuracy and relevant data on the efficacy of the novel drug application, thereby offering a reliable and reproducible alternative to traditional animal testing as well as a tool for further development and optimization. 

By integrating this validated platform into GMP workflows, the project is poised to significantly reduce the reliance on early-stage animal models, streamline preclinical testing, and shorten pharmaceutical development cycles. This advancement addresses a critical bottleneck in the transdermal drug delivery pipeline, enabling faster, safer, and more cost-effective development of personalized, non-invasive therapies.

Ultimately, the project promises substantial societal and industry-wide benefits: improved patient outcomes through tailored drug delivery, reduced ethical and financial burdens associated with animal testing, and enhanced innovation capacity for pharmaceutical companies seeking to bring novel therapies to market. 

 

Picture left: Maryam Ghasemzadeh Hasankolei, Tissue engineer Oerobionics 

Picure right: Natasha Rus, Technician cell material interaction 
Photocredits: SBMC